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24. Sekar Kathiresan, MD: Pioneering Single Dose Medications to Cure Cardiovascular Disease

In this conversation, Daniel Belkin and Mitch Belkin speak with Sekar Kathiresan, MD, about using gene editing medications to treat cardiovascular disease. We discuss Dr. Kathiresan’s company Verve Therapeutics, which has pioneered a lipid nanoparticle delivery system of a CRISPR-based gene editing technology. We delve into the pathophysiology of cardiovascular disease, the role played by LDL and the LDL receptor in atherosclerosis, the genetics underlying monogenic and polygenic risk for myocardial infarction, CRISPR and the future of gene editing technologies, and Verve’s ongoing phase I trial of a PCSK9 gene editing medication (VERVE-101) in humans.

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Who is Sekar Kathiresan?

Dr. Sekar Kathiresan, a cardiologist, geneticist, and the CEO and co-founder of Verve Therapeutics. Verve Therapeutics is a company pioneering a new approach to the treatment of cardiovascular disease with single-dose gene editing medications. Prior to co-founding Verve, he served as the director of the Massachusetts General Hospital Center for Genomic Medicine and was a Professor of Medicine at Harvard Medical School. 

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20. Jason Ryan, MD: Physician Entrepreneurship, Boards and Beyond, and How to Improve Medical Education

In this conversation, Mitch Belkin and Daniel Belkin speak with Dr. Jason Ryan, the creator of Boards and Beyond. We discuss how he started Boards and Beyond, what aspects of medical education are in need of reform, and why he is bullish on med ed entrepreneurship. 

In this episode, we cover Dr. Ryan’s background, his roots in chemical engineering, and how he decided on internal medicine and cardiology. We delve into how Dr. Ryan started Boards and Beyond, as his first entrepreneurial venture in 2014. He discusses why and how he began the medical education company, how he incorporates feedback into the product, as well as the difficulties he has encountered running the business. We touch on problems with standardized testing, how residency programs evaluate applicants, and why attendings struggle to evaluate medical students. Finally, we discuss how to reduce costs in medical school and the difficulties medical schools have in finding medical preceptors.

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Who is Jason Ryan?

Dr. Jason Ryan is a general cardiologist and an Associate Professor of Medicine at the University of Connecticut. He received his MD and MPH from University of Connecticut before completing his postdoctoral training at Harvard’s Beth Israel Deaconess Medical Center in Boston. Dr. Ryan is a gifted medical educator and the creator of Boards and Beyond, a video subscription service that provides a comprehensive review of USMLE Board topics. 

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14. Daniel Burka: How to Design Successful and User-friendly Healthcare Applications

In this episode, Mitch Belkin and Daniel Belkin speak with Daniel Burka about his work at Resolve to Save Lives and the project Simple.org, a hypertension reduction application. They discuss the importance of iterative building processes that trial various ideas and then quantifiably measure success. Daniel Burka stresses the importance of understanding the goals of all users–physicians, patients, public healthcare experts–when designing successful healthcare applications.

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Who is Daniel Burka?

Daniel Burka is the director of product and design at Resolve To Save Lives, where he works on the web-based, open-source hypertension reduction application Simple.org. Previously, he was a Design Partner at Google Ventures, the Creative Director for Digg.com, and the Director of Design for Tiny Speck which later became Slack. Among many notable projects, he designed the Firefox logo and Mozilla’s website.

What is Resolve to Save Lives?

Resolve to Save Lives is an initiative to prevent 100 million cardiovascular deaths over the next 30 years. The initiative is funded by Bloomberg Philanthropies, the Bill & Melinda Gates Foundation, Gates Philanthropy Partners, and the Chan Zuckerberg Foundation. Methods to reduce deaths include hypertension reduction, trans fat elimination, and sodium reduction initiatives. In addition, Resolve to Save Lives aims to increase epidemic preparedness.

What is Simple.org?

Simple.org is a project of Resolve to Save Lives. It is an ultralight weight electronic health record system designed to manage patients with hypertension and diabetes. As of January 2022, 1.4 million patients in India, Bangladesh, and Ethiopia use the application.

What is DHIS2?

District Health Information Software 2 (DHIS2) is a free, open-source health management data platform. It was initially developed for three health districts in Cape Town, South Africa in 1998-99, but has since spread to more than 40 countries in Africa, Asia and Latin-America, as well as the EU. DHIS2 is used to aggregate statistical data collection, analysis, management, and visual presentation. It is completely web-based and has the ability to create analysis from live data in seconds. In addition, DHIS2 can be used to monitor patient health outcomes, improve disease surveillance, map disease outbreaks, and speed up health data access for health facilities and government organizations. 

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