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27. Paul Offit, MD: The Cost of Medical Innovation, DDT and Malaria, and Bivalent Covid-19 Boosters

In this conversation, Daniel Belkin and Mitch Belkin interview Paul Offit, MD about his book You Bet Your Life, how banning DDT caused increased deaths from malaria, and the data regarding the bivalent booster as of October 2022. They discuss the human price paid for medical advances, sins of commission versus sins of omission, which populations should get bivalent boosters, short versus long incubation period viruses, vaccine-related myocarditis, and much more.

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Who is Paul Offit?

Dr. Offit is the Director of the Vaccine Education Center and an attending in the Division of Infectious Diseases at the Children’s Hospital of Philadelphia. He is on the FDA’s Vaccines and Related Biological Products Advisory Committee. In addition, he was the co-inventor of the RotaTeq vaccine for rotavirus, has published over 130 papers in medical and scientific journals, and is the author of many books on vaccines, antibiotics, medical overuse, and medical history, including You Bet Your Life.

If you didn’t see our initial episode with Dr. Paul Offit, check it out.

References:

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8. John Mandrola, MD: Medical Conservatism, Myocarditis, and Physician Advocacy

In this interview, Daniel Belkin and Mitch Belkin speak with Dr. John Mandrola about a 2019 article he co-authored entitled The Case for Being a Medical Conservative. They discuss concerns about vaccine-induced myocarditis in children, vaccine mandates, and whether the AMA and other physician organizations should take sides on controversial political issues. This conversation with Dr. Mandrola was recorded on July 11th, 2021.

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Who is John Mandrola?

Dr. John Mandrola is a practicing cardiac electrophysiologist and a regular columnist for theheart.org on Medscape. He hosts the fantastic “This Week in Cardiology” podcast and is a blogger at drjohnm.org. He completed his medical training in Internal Medicine, Cardiology and Electrophysiology at Indiana University. 

References:

The CAST trial 

RECOVERY Trial

Medscape – Cardiology

Medscape – General Medicine

Blog

Substack

This Week In Cardiology Podcast

Twitter: @drjohnm

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7. The Epigenetics of Aging & Dispelling mRNA Vaccine Myths with Yuri Deigin

In this External Medicine Podcast interview, Daniel Belkin and Mitch Belkin speak with Yuri Deigin about aging, which he argues is fundamentally an epigenetic phenomenon. They discuss partial reprogramming using Yamanaka factors, evolutionary explanations of aging, and recent in vivo experiments which suggest that aging is partially reversible. They also touch on mRNA vaccines, specifically to address allegations about the cytotoxicity of the spike protein and concerns about infertility discussed on Bret Weinstein’s Dark Horse Podcast with Steve Kirsch and Robert Malone, MD, recorded on June 11th 2021. This conversation with Yuri Deigin was recorded on June 25th, 2021.

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Who is Yuri Deigin?

Yuri Deigin is a biotech entrepreneur with a background in pharmaceutical development. He received degrees in computer science and mathematics from the University of Toronto and an MBA from Columbia University. He is the CEO of Youthereum Genetics, a company which aims to translate epigenetic rejuvenation therapies to humans. 

Yuri was an early proponent of the SARS-CoV-2 lab leak hypothesis, the idea that the virus may have inadvertently escaped from a lab. In April 2020, he published a detailed genomic analysis of SARS-CoV-2. In that article, Yuri discusses the virus’s furin cleavage site, genetic similarities and differences with its closest relative (RaTG13), and the similarities between the virus’s receptor binding motif and that of a pangolin respiratory virus. He also explores the gain-of-function research program at the Wuhan Institute of Virology. Unfortunately, we did not have time in this conversation to delve into this hotly debated topic.

References:

Universal methylation age across mammalian species

Partial reprogramming of Progeria mice

David Sinclair paper on restoring vision in mice

Uri Manor Lab spike protein paper 

Large doses of Spike Protein Induce Acute Lung Injury in Mice

Pfizer ADME study (translated from Japanese) 

Vaccine Adverse Event Reporting System (VAERS) FAQ re: requirement to report deaths, other serious adverse events

How frequently are side effects reported to VAERS?

More on Yuri:

Medium article on SARS-CoV-2 Origins

Yuri’s twitter: @ydeigin

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4. The Invisible Graveyard: A Conversation with Economist Alex Tabarrok

In this interview, we speak with Professor Alex Tabarrok about what an economist can bring to discussions about the pandemic, the US government’s response to COVID-19, the performance of the FDA and the CDC, regulatory nationalism, the first doses first campaign, and why America should vaccinate the world. This conversation was recorded on May 2nd, 2021.

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Who is Alex Tabarrok?

Professor Alex Tabarrok is the Bartley J. Madden Chair in Economics at the Mercatus Center and a professor of economics at George Mason University. He is the co-author of the popular economics blog Marginal Revolution and co-founder of Marginal Revolution University. He is the author of numerous academic papers in the fields of law and economics, criminology, regulatory policy, voting theory and other areas in political economy. His articles have appeared in the New York Times, the Washington Post, the Wall Street Journal, and many other publications.

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3. When Modern Medicine Goes Too Far: A Discussion with Paul Offit, MD

In this interview, Mitch Belkin and Daniel Belkin talk with Dr. Paul Offit about mRNA vaccine technology as well as a number of topics from his book, Overkill: When Modern Medicine Goes Too Far. We discuss the use of antipyretics to treat a fever, the overuse of antibiotics, vitamin D and C, as well as cancer screening. This conversation was recorded on April 5, 2021. 

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Who is Paul Offit?

Dr. Paul Offit is a pediatrician at the University of Pennsylvania specializing in infectious diseases, vaccines, immunology, and virology. He is the co-inventor of the RotaTeq vaccine for rotavirus, has published more than 130 papers in medical and scientific journals, and he is the author or co-author of books on vaccines, vaccination, and antibiotics. To learn more about Dr. Offit, visit his website.