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Podcast

33. Ross Levine, MD, PhD: Deep Dive on Acute Myeloid Leukemia

Ross Levine

In this conversation, Daniel Belkin and Mitch Belkin interview Ross Levine, MD, PhD about Acute Myeloid Leukemia and its treatment. They discuss the different types of leukemias, the history of AML treatment, including chemotherapy and stem cell transplantation. They touch on Graft vs Host Disease, treatment after relapse, and open questions in leukemia, including future trials, and further investigation of ven/aza (Azacitidine/venetoclax).

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Who is Ross Levine?

Dr. Ross Levine of the Memorial Sloan Kettering Cancer Center. Dr. Levine studies hematologic malignancies and is a world-renowned expert on myeloproliferative neoplasms and acute myeloid leukemia. 

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32. Adam J Brown, MD: History of Rheumatology, The Black Death, and Why You Shouldn’t Inject Uric Acid Crystals into Your Knee

Adam J Brown

In this conversation, Daniel Belkin and Mitch Belkin interview Adam J Brown, MD about the field of Rheumatology, autoimmune diseases, and his podcast Rheuminations. They discuss the history of gout, plaquenil, the relationship between infectious diseases and rheumatologic conditions, the inflammasome, autoinflammatory disorders, vasculitis, fibromyalgia, Covid, and much more.

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Who is Adam J Brown?

Dr. Adam J. Brown is a Rheumatologist at the Cleveland Clinic. Dr. Brown is the author of the book Rheumatology Made Ridiculously Simple. He is also the host of the Healio podcast Rheuminations, which focuses on autoimmunity, rare diseases, and the history of medicine. 

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Podcast

31. Saloni Dattani: Peer Review, Division of Labor in Science, and the Genetics of Psychiatric Disorders

Saloni Dattani

In this conversation, Daniel Belkin and Mitch Belkin interview Saloni Dattani about the genetics of psychiatric disorders and how to improve science. They discuss the lack of division of labor in academia, the history of peer review, ways to improve peer review, human challenge trials, and much more.

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Who is Saloni Dattani?

Saloni Dattani is a PhD student at King’s College London. She is the founding editor of the online magazine Works in Progress. She is also an editor at Stripe Press and a researcher at Our World in Data. 

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Podcast

30. Polly Matzinger, PhD: Dangerous Ideas in Immunology

Polly Matzinger

In this conversation, Daniel Belkin and Mitch Belkin interview Polly Matzinger, PhD, about her model of immunology, which she calls ‘The Danger Model’. They discuss how The Danger Model helps explain aspects of immunology ignored by the self/non-self model, including why mothers don’t reject their fetuses, autoimmune diseases, organ transplant rejection, cancer surveillance, allergy and more.

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Who is Polly Matzinger?

Polly Matzinger received her PhD in Biology from UCSD before completing a postdoc at Cambridge. She then worked at the Basel Institute for Immunology before moving to the NIH, where she was a section head at the National Institute of Allergy and Infectious Diseases of the so-called “Ghost Lab”. She is the creator of the Danger Model (1994), which argues the immune system discriminates between dangerous and safe by recognition of pathogens or alarm signals from injured or stressed cells and tissues. 

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Podcast

29. Derek Lowe, PhD: A Medicinal Chemist’s Thoughts on Drug Discovery and the Future of Pharma

Derek Lowe

In this conversation, Daniel Belkin and Mitch Belkin interview Derek Lowe, PhD, about drug discovery, clinical trials, drug patents, Alzheimer’s disease, the FDA, and his blog “In The Pipeline”. They discuss the potential role for machine learning in pharmaceutical development, whether Big Pharma spends excessively on marketing, and much much more. 

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Who is Derek Lowe?

Derek Lowe, PhD, is a medicinal chemist who works in preclinical drug discovery. He received a PhD in organic chemistry from Duke University and completed a Humboldt Fellowship in Germany for his post-doc. His blog about the pharmaceutical industry “In The Pipeline” has been continuously operating since 2002. 

References:

Derek Lowe’s Blog 

Twitter @DerekLowe

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