Category: Podcast

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Podcast

29. Derek Lowe, PhD: A Medicinal Chemist’s Thoughts on Drug Discovery and the Future of Pharma

Derek Lowe

In this conversation, Daniel Belkin and Mitch Belkin interview Derek Lowe, PhD, about drug discovery, clinical trials, drug patents, Alzheimer’s disease, the FDA, and his blog “In The Pipeline”. They discuss the potential role for machine learning in pharmaceutical development, whether Big Pharma spends excessively on marketing, and much much more. 

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Who is Derek Lowe?

Derek Lowe, PhD, is a medicinal chemist who works in preclinical drug discovery. He received a PhD in organic chemistry from Duke University and completed a Humboldt Fellowship in Germany for his post-doc. His blog about the pharmaceutical industry “In The Pipeline” has been continuously operating since 2002. 

References:

Derek Lowe’s Blog 

Twitter @DerekLowe

Can a biologist fix a radio?

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Podcast

28. Jean Hébert, PhD: Aging, Brain Plasticity, and Replacing the Neocortex

Jean Hebert

In this conversation, Daniel Belkin and Mitch Belkin interview Jean Hébert, PhD about aging, brain plasticity, and progressive neocortical replacement. They discuss one hallmark of aging—extracellular matrix damage—as well as how tissue replacement is a possible solution to aging. In addition, they explore the practicalities of progressive neocortex replacement, dopaminergic neuron transplants in Parkinson’s patients, and Professor Hébert’s work on stroke.

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Who is Jean Hébert?

Jean Hebert, PhD, is a Professor of Neuroscience and Genetics at the Albert Einstein College of Medicine where he focuses on age-related brain degeneration in the adult neocortex. He is one of the world’s leading researchers on brain cell and tissue replacement. He is the author of the book Replacing Aging.

References:

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Podcast

27. Paul Offit, MD: The Cost of Medical Innovation, DDT and Malaria, and Bivalent Covid-19 Boosters

Paul Offit

In this conversation, Daniel Belkin and Mitch Belkin interview Paul Offit, MD about his book You Bet Your Life, how banning DDT caused increased deaths from malaria, and the data regarding the bivalent booster as of October 2022. They discuss the human price paid for medical advances, sins of commission versus sins of omission, which populations should get bivalent boosters, short versus long incubation period viruses, vaccine-related myocarditis, and much more.

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Who is Paul Offit?

Dr. Offit is the Director of the Vaccine Education Center and an attending in the Division of Infectious Diseases at the Children’s Hospital of Philadelphia. He is on the FDA’s Vaccines and Related Biological Products Advisory Committee. In addition, he was the co-inventor of the RotaTeq vaccine for rotavirus, has published over 130 papers in medical and scientific journals, and is the author of many books on vaccines, antibiotics, medical overuse, and medical history, including You Bet Your Life.

If you didn’t see our initial episode with Dr. Paul Offit, check it out.

References:

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Podcast

26. Carl Schneider, JD: Patient Decision-Making, Questioning Informed Consent, and Why IRBs Should Be Abolished

Carl Schneider

In this colorful conversation, Daniel Belkin and Mitch Belkin speak with Carl Schneider, JD about informed consent and the problematic nature of IRBs. We discuss the difficulties of patient education and whether patients actually want medical knowledge in order to guide their decision-making. We discuss the onerousness of IRB regulation, event licensing, the costs of inhibiting knowledge generation, as well as the paternalism of IRBs. We cover how “protections” for vulnerable groups counterintuitively harms these groups by preventing both the generation of knowledge and the development of treatments. Professor Schneider argues that IRBs should be abolished and the system of informed consent ought to be reconsidered.

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Who is Carl Schneider?

Professor Carl Schneider is a lawyer and bioethicist. He is a Professor of Ethics, Morality, and the Practice of Law at University of Michigan. After attending University of Michigan Law School, he served as law clerk to Justice Potter Stewart of the United States Supreme Court. Schneider has authored several books, including The Censor’s Hand: The Misregulation of Human-Subject Research and The Practice of Autonomy: Patients, Doctors, and Medical Decisions.

References

If you enjoyed this episode, be sure to check out our episode with Simon Whitney.

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Podcast

25. Adam Cifu, MD: On Ending Medical Reversals and Reimagining Medical Education

Adam Cifu

In this conversation, Daniel Belkin and Mitch Belkin speak with Adam Cifu, MD, about how to improve medical education, the importance of evidence-based medicine, and medical reversals. We discuss his collaboration with Vinay Prasad, MD, why we should swap the order of medical school curricula, and landmark trials that changed his clinical practice.

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Who is Adam Cifu?

Adam Cifu a general internist and professor of medicine at the University of Chicago. He is a clinical educator, a podcast host, and the author of over 100-peer reviewed articles as well as two books: Ending Medical Reversal: Improving Outcomes, Saving Lives (2015) and Symptom to Diagnosis: An Evidence Based Guide (4th Edition, 2019).

References